Agrippine Putricia Asaeli and Anita Yuliati and Theresia Indah Budhy S. and Safira Wilda and Imam Silalahi and Demitria Santoso (2019) The Profile of Cross-Linked Chitosan and Collagen Derived-Chicken Shank Scaffold as Biomaterials in Tissue Engineering. Journal of International Dental Medical Research, 12 (1). pp. 6-11. ISSN 1309 – 100X

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Abstract

Periodontitis, congenital disorder, degenerative disease, and bone tumor are the major problems in oral cavity that could damage bone continuity. The damage is irreversible and in most cases the bone cannot heal properly, so a biomimetic scaffold is needed to mediate the healing process. Scaffold made of chitosan and collagen derived-chicken shank (CDCS) is on a development in recent Researches. Scaffold combined with 0.25% glutaraldehyde as cross linking agent shows a good improvement in biologic and mechanical properties. The aim of this study is to discover the profile of cross-linked chitosan-CDCS scaffold as biomaterial in tissue engineering. Methods: Scaffolds’ profiles were examined with degradation test, swelling test, WCP test and porosity size by using SEM. These scaffolds have degradation rate 20.909%, swelling ratio 1.625, WCP 59.851%, and porosity size36.06μm. The profile of cross-linked chitosan-CDCS scaffold seem to fulfill the requirements as biomaterial for tissue engineering.

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