Edward Muliawan Putera and Iswan Abbas Nusi and Poernomo Boedi Setiawan and Herry Purbayu and Titong Sugihartono and Ummi Maimunah and Ulfa Kholili and Budi Widodo and Husin Thamrin and Amie Vidyani and Muhammad Miftahussurur (2017) Termination of Antiviral Administration in Chronic Hepatitis B. In: Proceedings of The Surabaya International Physiology Seminar. SCITEPREES-Science and Technology Publications, Lda., Surabaya, pp. 431-437. ISBN 978-989-758-340-7

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Abstract

Virus Hepatitis B (VHB) eradication still cannot be achieved under current clinical guidelines due to the typical virus life cycle. Four phases of disease in chronic hepatitis B infection have been used as guidance in preparing therapy indications. Virus suppression with a nucleoside analog (NA) is an important part of chronic hepatitis B therapy, but the high post-termination recurrence rate of NA results in an unlimited duration of therapy. Long-term NA therapy results in various problems such as resistance, reduced adherence, side-effects, and economic burden for patients. The latest findings add to the possibility of larger HBsAg seroconversion after the termination of NA therapy. Various guidelines provide guidance on the termination of NA therapy. It is stated that the termination of NA therapy can be performed using strict surveillance methods for individuals who have undergone antiretroviral therapy after which follows HBeAg seroconversion, minimal amount of VHB DNA, non-cirrh osis status, and normal ALT levels

Item Type:	Book Section
Uncontrolled Keywords:	Antiviral, chronic hepatitis b, ALT, VHB DNA, NA
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Divisions:	01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:	Creators NIM Edward Muliawan Putera NIM011328026302 Iswan Abbas Nusi NIDN0028025003 Poernomo Boedi Setiawan NIDN8886900016 Herry Purbayu NIDN8884800016 Titong Sugihartono NIDN8836800016 Ummi Maimunah NIDN8896900016 Ulfa Kholili NIDN0004047511 Budi Widodo NIDN8804800016 Husin Thamrin NIDN8825800016 Amie Vidyani NIDN0028018002 Muhammad Miftahussurur NIDN0029097909
Depositing User:	arys fk
Date Deposited:	06 Dec 2019 03:18
Last Modified:	06 Dec 2019 03:18
URI:	http://repository.unair.ac.id/id/eprint/91960
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