Mukhammad Burhanuddin and Iswan Abbas Nusi and Poernomo Boedi Setiawan and Herry Purbayu and Titong Sugihartono and Ummi Maimunah and Ulfa Kholili and Budi Widodo and Muhammad Miftahussurur and Husin Thamrin and Amie Vidyani (2017) Pharmacological Therapy of Portal Hypertension. In: Proceedings of The Surabaya International Physiology Seminar. SCITEPREES-Science and Technology Publications, Lda., Surabaya, pp. 389-396. ISBN 978-989-758-340-7

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Abstract

Portal hypertension is a clinical syndrome characterized by pathological elevation of portal venous pressure and all its consequences. In portal hypertension, there is an increase in pressure in the veins that carry blood from the splanchnic organs to the liver. The main factors of portal hypertension include increased intrahepatic resistance to portal blood flow due to degenerative nodules and increased splanchnic blood flow secondary to vasodilation in the splanchnic vascular bed. Clinical symptoms indicated in portal hypertension are varicella hemorrhage with hematemesis or vomiting of blood (vomitus may be red blood mixed with clumps or coffee grounds), and/or melena, i.e. red or black defecation-like petis (shrimp paste). The goal of treatment of patients with portal hypertension is to reduce portal pressure. Drugs for portal hypertension should be able to lower blood vessel portal pressure without lowering arterial pressure, which may aggravate hyperdynamic circulation and incre ase the risk of renal failure. Most of the drugs often used in clinical practice are splanchnic vascular vasoconstrictors vasopressin derivatives (terlipressin), somatostatin, somatostatin analogs (octreotide and vapreotide), Nonselective β-Blocker and Carvedilol.

Item Type:	Book Section
Uncontrolled Keywords:	Portal hypertension, splanchnic vascular bed, pharmacological therapy, nonselective β-blocker, propranolol
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Divisions:	01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:	Creators NIM Mukhammad Burhanuddin UNSPECIFIED Iswan Abbas Nusi NIDN0028025003 Poernomo Boedi Setiawan NIDN8886900016 Herry Purbayu NIDN8884800016 Titong Sugihartono NIDN8836800016 Ummi Maimunah NIDN8896900016 Ulfa Kholili NIDN0004047511 Budi Widodo NIDN8804800016 Muhammad Miftahussurur NIDN0029097909 Husin Thamrin NIDN8825800016 Amie Vidyani NIDN0028018002
Depositing User:	arys fk
Date Deposited:	06 Dec 2019 00:54
Last Modified:	06 Dec 2019 00:54
URI:	http://repository.unair.ac.id/id/eprint/92012
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