Rizki Amalia and Wurlina and Eka Pramyrtha Hestianah (2017) Efek Pemberian Vitamin C dan Vitamin E terhadap Gambaran Histopatologi Duodenum Mencit yang di papar Boraks. Veterinaria Medika, 10 (1). pp. 23-30. ISSN 1979-1305

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Abstract

The aim of this research was to investigate the effect of vitamin C and E towards histopathological changes of duodenum in mice induced with borax. Twenty five male mice of BALB/c strain divided into five groups; KI (vitamin control) was given 0,56 mg/ mice /day of vitamin C solution combinated 2,1 mg/mice/day of vitamin E solution, K2 (borax control) was given 5,2 mg/mice/day of boraks, PI was given combination of 0,56 mg/mice/day vitamin C and 2,1 mg/mice/day vitamin E solutions and 5,2 mg/mice/ day of borax, P2 was given combination of 1,12 mg/mice /day of vitamin C and 4,2 mg/mice/ day of vitamin E solutions and 5,2 mg/mice/day of borax, P3 was given combination of 2,24 mg/mice/day of vitamin C and 4,2 mg/mice/day of vitamin E solutions and 5,2 mg/mice/day of borax. Borax solution on P3, P4 and P5 groups induced in an hour after each groups treated with combination of vitamin C and E solutions. The treatment were given by oral gavage for 14 days. The result against submucosal edema of duodenum indicated there was not any significant difference (P>0.05) between KI (vitamin control) and K2 (boraks control) groups. There was a signifant difference between K2 (borax control) with PI and P3 groups. There was indicated that vitamin C and E decrease the submucosal edema of duodenum induced with borax. The result against the damage of mucous epithelial indicated there was a significant difference (P<0,05) between K2 group with PI, P2, and P3 groups. There was not any significant difference between P1, P2, and P3 groups. There was indicated that vitamin C and vitamin E could repair the submucosal edema of duodenum induced with boraks. Keywords: Vitamin E, vitamin C. submucosal edema, mucous epithelial, boraks

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