Eka Pramyrtha Hestianah (2012) Histopathology OF Hepatocyte Nucleus Degeneration Exposed by Curcuma aeruginosa. Prosiding Internasional Seminar International Strategy to Manage Bio-eco-health System for Stabilizing animal Health and Productivity to Support Public Health. pp. 70-72. ISSN 978-602-8967-69-3

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Abstract

This research is aimed at finding out the effect of Curcuma Aeruginosa given to the hispathology hepatocyte of 40 male mice, weight 2s-30 g. The mice are divided into 5 treatment groups namely I control group, 2 infused groups and 2 squeezed groups. Curcuma Aeruginosa is given once a day and on day 11, the livers of the mice are taken and made into histopathology preparation with HE staining. The data taken are analyzed by manovafactorial and anova one way. The result shows the occurrence of hepatocyte nucleus degeneration, the highest means of karyopicnosis and karyorhexis on infused group of 10 mg/25 g body weight, are 10.22% and 49.6% (a = 0.05). The highest karyolysis on infused and squeezed groups of 10 mg/25 g body weight, is 45.86% and 45.70% (a-0.05). The conclusion is that infused and squeezed Curcuma Aeruginosa given orally to male mice has caused the hepatocyte nucleus degeneration. Keywords: Hepatocyte, nucleus degeneration, curcuma aeruginosa, mice

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