M. Zainul Amrullah (2015) Karakterisasi Sistem Dispersi Padat Quercetin-Peg 8000. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The flavonol quercetin is potentially clinically relevant for its antioxidant activity, antiinflamation, and others. However, its beneficial properties for therapeutic applications have been impended by the fact that quercetin has poor aqueous solubility and low bioavailability. Solid dispersions of quercetin-PEG 8000 suggest way to increase quercetin solubility and bioavailability. The aim of this investigation is to get characterization of quercetin-PEG 8000 solid dispersions that were prepared by melting method. They were characterized by differential thermal analysis, powder X-ray diffraction, scanning electron microscope, and fourier transform infrared spectroscopy. The result was seen that solid dispersion has low melting point, decrease of difractogram intensity, reduced particle size than quercetin and physical mixture. The infrared spectra of solid dispersions and physical mixtures are shown that the bands of quercetin were visible on their spectra and also the spectra were maintained.

Item Type:	Thesis (Skripsi)
Additional Information:	KKB KK-2 FF.F.23/15 Amr k
Uncontrolled Keywords:	CHQuercetin, PEG 8000, Solid Dispersion, Physical characterization
Subjects:	Q Science > QD Chemistry > QD415-436 Biochemistry
Divisions:	05. Fakultas Farmasi > Farmastika
Creators:	Creators NIM M. Zainul Amrullah NIM051111120
Contributors:	Contribution Name NIDN / NIDK Thesis advisor Dwi Setyawan NIDN0030117104 Thesis advisor Helmy Yusuf NIDN0015077901
Depositing User:	Nn Dhani Karolyn Putri
Date Deposited:	19 Feb 2016 12:00
Last Modified:	19 May 2020 05:20
URI:	http://repository.unair.ac.id/id/eprint/9275
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