Ahmad Raihan (2015) Uji Hepatotoksik Campuran Ekstrak Kering Daun Kumis Kucing (Orthosiphon Stamineus) Dan Perikarpium Manggis (Garcinia Mangostana L.) Terhadap Mencit (Mus Musculus). Skripsi thesis, UNIVERSITAS AIRLANGGA.
![[img]](https://repository.unair.ac.id/style/images/fileicons/text.png) |
Text
1. HALAMAN JUDUL .pdf Download (386kB) |
|
Text
2. ABSTRAK .pdf Download (113kB) |
|
Text
3. DAFTAR ISI .pdf Download (149kB) |
|
Text
4. BAB I .pdf Download (139kB) |
|
Text
5. BAB II .pdf Download (464kB) |
|
Text
6. BAB III .pdf Download (114kB) |
|
Text
7. BAB IV .pdf Download (206kB) |
|
Text
8. BAB V .pdf Restricted to Registered users only until 21 April 2023. Download (579kB) | Request a copy |
|
Text
9. BAB VI .pdf Restricted to Registered users only until 21 April 2023. Download (101kB) | Request a copy |
|
Text
10. DAFTAR PUSTAKA .pdf Download (160kB) |
|
Text
11. LAMPIRAN .pdf Restricted to Registered users only until 21 April 2023. Download (272kB) | Request a copy |
Abstract
Hepatotoxicity is one of the serious adverse effect of the drugs. The aim of the research was to determined hepatotoxic effect of from the mixture from dry extract of Garcinia mangostana Linn and Orthosiphon stamineus Benth in male white mice (Mus musculus). In this research, 24 mice were divided randomly into 4 groups with 1 control group and 3 groups with different doses (23 mg/kg BW; 69 mg/kg BW; and 115 mg/kg BW) given treatment orally of mixture from dry extract of Garcinia mangostana Linn and Orthosiphon stamineus Benth during 28 days with ratio 1:1. The mice were sacrificed on the twenty ninth day to analyze transaminase enzymes (SGOT and SGPT) and macroscopic appearance and histopatological of liver. Data was analyzed using One Way Anova test and Kruskal-Wallis. The result of biochemical analysis in the blood levels of SGOT and SGPT increased but remained are within normal limit. Result statistically analyzed by Anova test for SGOT and SGPT showed there were not significantly difference between groups. The result showed present light necrosis and degeneration on all of the group treatment. Result of statistically analyzed by Kruskal-Wallis test showed there were not significantly difference for histopathological of liver. The conclusion is mixture from dry extract of Garcinia mangostana Linn and Orthosiphon stamineus Benth in 1:1 ratio with doses equivalent to 23 mg/20g body weight; 69 mg/20g body weight and 115 mg/20g body weight had no hepatotoxic effect on male mice’s liver.
| Item Type: | Thesis (Skripsi) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Additional Information: | KKB KK-2 FF.FT.11/15 Rai u | |||||||||
| Uncontrolled Keywords: | Garcinia mangostana Linn., Orthosiphon stamineus Benth.,hepatotoxic effect in mice, SGOT, SGPT. | |||||||||
| Subjects: | Q Science > QD Chemistry > QD415-436 Biochemistry Q Science > QK Botany > QK1-989 Botany S Agriculture > SF Animal culture > SF405.5-407 Laboratory animals |
|||||||||
| Divisions: | 05. Fakultas Farmasi > Farmakognosi Fitokimia | |||||||||
| Creators: |
|
|||||||||
| Contributors: |
|
|||||||||
| Depositing User: | Nn Dhani Karolyn Putri | |||||||||
| Date Deposited: | 22 Feb 2016 12:00 | |||||||||
| Last Modified: | 21 Apr 2020 03:24 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/9291 | |||||||||
| Sosial Share: | ||||||||||
Actions (login required)
 |
View Item |