Bagas Aji Pamungkas (2015) Uji Aktivitas Antidiabetes Campuran Ekstrak Kering Daun Afrika (Vernonia Amygdalina D) Dan Kulit Buah Manggis (Garcinia Mangostana L) Pada Mencit (Mus Musculus) Yang Di Induksi Aloksan. Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Diabetes Mellitus (DM) is a chronic metabolic disorder characterized by high blood sugar levels as a result of insufficiency of insulin function. The present studies was carried out to evaluate combination of dry extract from Vernonia amygdalina D. and Garcinia mangostana L. for antidiabetic activity in alloxan induced diabetic mice. Alloxan was administered as a 120 mg/kg BW in buffer citrate to induce diabetes. Combinations dry extract of Vernonia amygdalina D and Garcinia mangostana L with ratio 1:1, 1:2 and 2:1 (9,4 mg/20g BW mice), were administered orally to groups I, II, III, respectively for seven days. The standardized drug glibenclamide (0,013mg/20g BW mice) and CMC-Na 0,5 % was also administered orally to mice as positive and negative control groups respectively. After repeated daily oral administrations of the extract (9,4 mg/20g BW mice) for seven days, the extract significantly reduced blood glucose level in diabetic mice from days 3 compared to negative control group. The dry extract of Vernonia amygdalina D and Garcinia mangostana L. with ratio 1:1 showed the biggest reduction in blood glucose level significant with percentage 56,0%. The combination with ratio 2:1 and 1:2 also reduced blood glucose level with percentage 38,3% and 31,8 %.
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK-2 FF.FT.20/15 Pam u | |||||||||
| Uncontrolled Keywords: | Vernonia amygdalina D., Garcinia mangostana L., antidiabetic activity., alloxan | |||||||||
| Subjects: | Q Science > QD Chemistry > QD1-999 Chemistry Q Science > QD Chemistry > QD415-436 Biochemistry S Agriculture > SF Animal culture > SF405.5-407 Laboratory animals |
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| Divisions: | 05. Fakultas Farmasi > Farmakognosi Fitokimia | |||||||||
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| Depositing User: | Nn Dhani Karolyn Putri | |||||||||
| Date Deposited: | 22 Feb 2016 12:00 | |||||||||
| Last Modified: | 21 Apr 2020 07:11 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/9300 | |||||||||
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