Fanny Rosalia W. (2015) Uji Aktivitas Antidiabetes Kombinasi Ekstrak Kering Perikarpium Buah Manggis (Garcinia mangostana Linn.) dan Ekstrak Kering Bawang Putih (Allium sativum Linn.) pada Mencit yang Di Induksi Aloksan. Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Diabetes mellitus is a group of metabolic disorder characterized by hyperglicemia and alteration in the carbohydrate, fat and protein metabolism associated with absolute or relatives deficiencies in insulin secretion or its action. The present studies was carried out to evaluate combination of dry extract from Gracinia mangostana and Allium sativum L. for antidiabetic activity in alloxan induced diabetic mice. Alloxan was administered as a 140mg/kg BW in buffer citrate to induce diabetes. Combination of dry extract Gracinia mangostana and Allium sativum L. with ratio 1:1, 1:2 and 2:1 (23,3mg/20g BW mice), was administered orally to groups I, II, III for seven days. The standardized drug glibenclamide (0,013mg/20g BW mice) and CMC-Na also administered orally to mice as positive and negative control group respectively. After repeated daily oral administrations of the extract (23,3mg/20g BW mice) for seven days, the extract significantly reduce blood glucose level in diabetic mice from days 5 compared to negative control group. The dry extract Gracinia mangostana and Allium sativum L. According to blood glucose level profile in mice alloxan inducted, the mixture of mangosteen (Garcinia mangostana) pericarp dry extract and garlic (Allium sativum) with ratio 2:1 (23,3 mg/kg BW mice) had the most effective activity to reduce blood glucose level in diabetic mice. The results indicate that dry extract of Gracinia mangostana and Allium sativum L dengan could be a good natural source developing as an antidiabetic drug that can effectively maintaned blood glucose levels to near normal value.
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK-2 FF.FT.31/15 Fan u | |||||||||
| Uncontrolled Keywords: | Gracinia mangostana, Allium sativum L., antidiabetic activity, dry extract | |||||||||
| Subjects: | Q Science > QD Chemistry > QD415-436 Biochemistry R Medicine > RC Internal medicine S Agriculture > SF Animal culture > SF405.5-407 Laboratory animals |
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| Divisions: | 05. Fakultas Farmasi > Farmakognosi Fitokimia | |||||||||
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| Depositing User: | Nn Dhani Karolyn Putri | |||||||||
| Date Deposited: | 24 Feb 2016 12:00 | |||||||||
| Last Modified: | 28 Feb 2020 07:02 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/9311 | |||||||||
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