Herlina Maulida Agustin (2015) Isolasi Dan Identifikasi Senyawa Alkaloida Fraksi C.9 Dari Fraksi Kloroform Daun Cassia Spectabilis. Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Cassia spectabilis is a plant from Genus Cassia that can be used for malarial remedies. C.spectabilis contain alkaloid. Previous study reported that methanolic extract of C.spectabilis leaves has antimalarial activity againts Plasmodium falciparum. This research focus on isolation of alkaloid from fraction C.9 of chloroform fraction of C.spectabilis leaves. Fraction C.9 showed antimalarial activity (IC50 0,012 μg/ml). Fraction C.9 was purified by preparative TLC. From this fraction, a alkaloid compound was isolated. Structure determination of the isolated compound was performed by 1H-NMR spectroscopy. The 1H-NMR spectrum exhibited signals at δH 3,75 ppm and δH 2,85 corresponding to a hydroxy methine. There were signal at δH 2,44 ppm and δH 2,11 ppm corresponding to methylen group with ketone and a methyl keton, respectively. There are methylene group observed at δH 1,3-1,4 ppm.1HNMR data comparison of the isolated compound to literature data showed that the structure of the isolated compound was similar to spectaline (piperidine alkaloid).
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK-2 FF.FT.44/15 Agu i | |||||||||
| Uncontrolled Keywords: | isolation, Cassia spectabilis, piperidine alkaloids | |||||||||
| Subjects: | Q Science > QD Chemistry > QD1-999 Chemistry Q Science > QK Botany > QK1-989 Botany |
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| Divisions: | 05. Fakultas Farmasi > Farmakognosi Fitokimia | |||||||||
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| Depositing User: | Nn Dhani Karolyn Putri | |||||||||
| Date Deposited: | 25 Feb 2016 12:00 | |||||||||
| Last Modified: | 23 Apr 2020 04:21 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/9324 | |||||||||
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