Aning Dwi Hartati (2015) Uji Aktivitas Antihiperkolesterolemia Kombinasi Ekstrak Kering Daun Orthosiphon Stamineus Benth. Dan Ekstrak Kering Umbi Allium Sativum Linn. Terhadap Mencit Yang Diinduksi Aloksan. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Hypercholesterolemia was defined as a state with an increase in cholesterol levels over the reference value, but is regarded as a high risk factor for coronary artery disease state is if the increase in cholesterol levels ≥ 240 mg / dl. The present studies was carried out to evaluate combination of dry extract from Orthosiphon stamineus Benth. and Allium sativum L. for antihypercholesterolemic activity in alloxan induced cholesterolemic mice. Alloxan was administered as a 150mg/kg BW in buffer citrate to induce hypercholesterolemic. Combination of dry extract Orthosiphon stamineus Benth. and Allium sativum L. with ratio 1:1, 1:2 and 2:1 (23,3mg/20g BW mice), was administered orally to groups I, II, III for seven days. The standardized drug atorvastatin (0,026mg/20g BW mice) and CMC-Na also administered orally to mice as positive and negative control group respectively. After repeated daily oral administrations of the extract (23,3mg/20g BW mice) for seven days, the extract significantly reduce blood cholesterol level in hypercholesterolemic mice at the 5 days compared to negative control group. The dry extract Orthosiphon stamineus Benth. and Allium sativum L. with ratio 1:1 showed the biggest reduction in blood cholesterol level (93,2 mg/dL) with percentage 38,48%. The combination with ratio 1:2 and 2:1 also have significant blood cholesterol level (70,8 mg/dL) with percentage 30,13% and (54,0 mg/dL) with percentage 23,34%, the combination were compared with standard drug atorvastatin (0,026mg/20g BW mice) have no significant to reduce blood cholesterol level. The results indicate that dry extract of Orthosiphon stamineus Benth. and Allium sativum L could be a good natural source developing as an antihypercholesterolemic drugs that can effectively maintain blood cholesterol levels.

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