Djoko Santoso and Ketut Sudiana and Muchammad Yunus (2019) The Effect of a Low Protein Diet on The Expression of IL-6, TNF-α and TGF-β in The Kidney Tissue of Mice Model. Malaysian Journal of Medicine and Health Sciences, 15 (1). pp. 46-52. ISSN 2636-9346

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Abstract

High prevalence of malnutrition has impact that often causes problems in body organs. Various reports suggest an association between malnutrition and chronic kidney failure. However, the effect of malnutrition on the immunological status of the kidney has not been identified. Objective: to identify the effect malnutrition on the immunological status of the kidney. Methods: It was an experimental study with post test only control group design to compare two dietaries intake in two mice groups. Group 1, mice were given with standard intake. Group 2, mice were fed with low protein diet. The variables analyzed were the expression of IL-6, TNF-α and TGF-β in kidney tissue by immunohistochemistry and comparative test using Mann-Whitney test. Results: Eleven dead mice were found in the low protein diet group until day 75. At the end of observation, the number of mice in control group remained 10, while, in malnutrition group, there were 9 mice which were still alive but in a state of malnutrition. Based on comparative test between the group receiving and not receiving low protein diet, it was found that the expression of IL-6, TNF-α and TGF-β in kidney tissue showed a significant difference (p<0.05). Conclusion: Low protein diet in malnutrition affects the immunological status of the kidney as marked by the expression of IL-6, TNF-α, and TGF-β in the kidney tissue of mice model. Keywords: Low protein diet, Kidney tissue, IL-6, TNF-α, TGF-β expression

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