Sugiyartono and Widji Soeratri and Muhammad Zainuddin (2017) The Effect of Combination of Methacrylic Acid Copolymer L Type and S Type On the Physical and Chemical Polymer Properties. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 8 (1). pp. 1648-1652. ISSN 0975-8585

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Abstract

The combination of methacrylic acid copolymers L-type and S-type in development of novel drug delivery system (NDDS) has been hold to modify the release pattern of drug. This combination especially for achieving dosage form release active substances in intestine. Physical and chemical properties of this copolymers has an important things because it can influence the quality of dosage form. Each of copolymers has different properties, so the combination will achieve the best formula. Methacrylic acid copolymer L-type has a number of methacrylic acid 49.6% and low viscosity 89 Mpa.s whereas methacrylic acid copolymer of Stype has a number of methacrylic acid 28.8% and a high viscosity 162 Mpa.s. To investigate the effect of the copolymer combination on the physical and chemical properties, the viscosity, acid number and pH of the matrices combination were then investigated. The combination of methacrylic acid copolymers L-type and Stype are: 10 : 0; 8 : 2; 6 : 4; 5 : 5; 4 : 6; 2: 8; and 0 : 10. The result showed that the increasing proportions of Stype (formula 1 to formula 7), increased the viscosity and pH, and decreased acid value.

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