Anggie Widhi and Noorma Rosita and Widji Soeratri (2014) Antioxidant Stability Assay of Alpha Tocopheryl Acetate In Solid Lipid Nanoparticle System (Lipid Base Beeswax and Monostearic Gliseryl 50:50). In: Proceeding The 1st International Conference on Pharmaceutics & Pharmaceutical Sciences. Faculty of Pharmacy Universitas Airlangga, Surabaya, pp. 8-12. ISBN 978-602-72333-0-0

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Abstract

Introduction : As an antioxidant, alpha tocopheryl acetate is easily degraded by light and free radical in air. Solid Lipid Nanoparticle (SLN) is a system that can provide protection of active ingredient because of its drug entrapment ability and physical protective from UV light due to its nano-sized. The aim of this study is for investigated the ability of SLN that could increase stability of antioxidant potency from alpha tocopheryl acetate. SLN is expected to have higher stability of antioxidant potency compared with simple cream. Methods : SLN and simple cream was made SLN was made using lipid beeswax (BW) and monostearic glyceryl (GMS) as base and Tween 80 as stabilizer. SLN was produced using high shear homogenization method and simple cream was produced using hot plate magnetic stirrer. Antioxidant potency was measured by DPPH method. Sample was radiated by UV C light as free radical initiator. Result and Discussion : Alpha tocopheryl acetate loaded in SLN system has higher stability of antioxidant potency compared with simple cream that shown with k value as constanta of antioxidant potency degradation between time This could be due to its physical blocker of UV light and drug entrapment properties. Conclusion : SLN was selected as antioxidant carrier due to its ability to increase antioxidant stability of alpha tocopheryl acetate.

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