Widji Soeratri and Mahrus Naufal Nuruddin and Diajeng Putri Paramita and Dwi Setyawan and Bambang Widjaja (2020) Optimization of Povidone K-30 and Sodium Starch Glycolate on Levofloxacin Tablet by Factorial Design. Jurnal Ilmu Dasar, 21 (1). pp. 35-42. ISSN 2442-5613

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Abstract

The aim of this study was to determine the effect of binder and disintegrant excipients towardtablet properties of levofloxacin as the latter tends to suffer brittle fracture upon compression. Theexcipients used were povidone K-30 as the binder and sodium starch glycolate (SSG) as thedisintegrant whichthe tablets were formulated according to factorial design 22with two factorsand two levels on each factor. Four formulas were prepared by wet granulation method using 2and 4% of each povidone K-30 and sodium starch glycolate in various compositions. Tablet properties were evaluated for its hardness, friability, and disintegration time as well as dissolution profile. The data obtained was statistically analyzed using Minitab®17 software to optimize theformulation and resulted in different impacts caused by each excipient. Povidone K-30 exhibitedan increment in hardness, friability, disintegration time but a decrease indissolution profile of levofloxacin tablet. SSG decreased hardness and disintegration time, but increased friability anddissolution profile of levofloxacin tablet. Overlaid contour plot showed that the optimal formularegarding tablet properties of friability, disintegration time, and dissolution profile is incomposition of 2.01% povidone K-30 and 2.01% sodium starch glycolate

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