Abdul Razak Kelana Ibrahim and Purnomo Budi Setiawan and Soebagijo Adi Soelistijo and Iswan Abbas Nusi and Ummi Maimunah and Herry Purbayu and Ulfa Kholili and Budi Widodo and Husin Thamrin and Muhammad Miftahussurur and Amie Vidyani (2019) Degree of chronic hepatitis c severity and insulin resistance. New Armenian Medical Journal, 13 (1). pp. 27-34. ISSN 18290825

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Abstract

Background: Diagnosis of fibrosis on chronic hepatitis C still needs invasive method such as liver biopsy. Aspartate Transaminase to Platelet Ratio Index (APRI) is a cheap and widely used assessment to indicate the presence of fibrosis in the liver. Insulin resistance as one an extra complication of chronic hepatitis C. We determined the correlation between degree of chronic hepatitis C severity based on APRI and the incidence of insulin resistance in chronic Hepatitis C patients. Methods: Degree of chronic hepatitis C severity was determined based on APRI and insulin resistance were determined using HOMA-IR. Correlation were analyzed using Chi-square and phi coefficient test, respectively. Results: Thirty chronic hepatitis C patients in this study consisted of in men was 16 male (53.3) and 14 female (46.7) patients with an average age of 51.63 ± 12.29. Frequency distributions of severity based on dominant APRI showed fibrosis in 18 patients (60) and no fibrosis in 12 patients (40). Insulin resistance distribution based on HOMA-IR showed no insulin resistance in 16 patients (53.3) and insulin resistance in 14 patients (46.7). There was a correlation between degree of chronic hepatitis C severity based on APRI and insulin resistance based on HOMA-IR with p = 0.006 and r = 0.491, respectively. Conclusion: There was a correlation between chronic hepatitis C severity based on APRI and insulin resistance based on HOMA-IR. © 2019, Yerevan State Medical University. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	bilirubin, adult; alanine aminotransferase blood level; albumin blood level; Article; aspartate aminotransferase blood level; chronic hepatitis C; clinical article; cross-sectional study; disease severity; female; glucose blood level; homeostasis model assessment; human; insulin blood level; insulin resistance; laboratory diagnosis; leukocyte; liver fibrosis; male; middle aged; observational study; thrombocyte
Subjects:	R Medicine > R Medicine (General) R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
Divisions:	Artikel Ilmiah > SCOPUS INDEXED JOURNAL
Creators:	Creators NIM Abdul Razak Kelana Ibrahim NIM011080213 Purnomo Budi Setiawan NIDN8886900016 Soebagijo Adi Soelistijo NIDN8837500016 Iswan Abbas Nusi NIDN0028025003 Ummi Maimunah NIDN8896900016 Herry Purbayu NIDN8884800016 Ulfa Kholili NIDN0004047511 Budi Widodo NDIN8804800016 Husin Thamrin NDIN8825800016 Muhammad Miftahussurur NIDN0029097909 Amie Vidyani NIDN0028018002
Depositing User:	PPJPI
Date Deposited:	06 Mar 2020 00:52
Last Modified:	06 Mar 2020 00:52
URI:	http://repository.unair.ac.id/id/eprint/94586
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