Muhammad Miftahussurur and Dalla Doohan, Dalla Doohan and Iswan Abbas Nusi, Iswan Abbas Nusi and Pangestu Adi, Pangestu Adi and Yudith Annisa Ayu Rezkitha, Yudith Annisa Ayu Rezkitha and Langgeng Agung Waskito, Langgeng Agung Waskito and Kartika Afrida Fauzia, Kartika Afrida Fauzia and Taufan Bramantoro, Taufan Bramantoro and Ummi Maimunah, Ummi Maimunah and Husin Thamrin, Husin Thamrin and Safitri Indah Masithah, Safitri Indah Masithah and Sukadiono, Sukadiono and Tomohisa Uchida, Tomohisa Uchida and Maria Inge Lusida, Maria Inge Lusida and Yoshio Yamaoka, Yoshio Yamaoka (2018) Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence. PLoS ONE, 13 (11). ISSN 19326203

Text Miftahussurur-Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence.pdf Download (679kB)

Abstract

The association between gastroesophageal reflux disease (GERD) prevalence and its risk factors in an area with low Helicobacter pylori prevalence is important to clarify. We analyzed the prevalence of GERD and risk factors in an area of Indonesia with low prevalence of H. pylori infection. We recruited 104 dyspeptic patients who underwent endoscopy in Surabaya. Patients were diagnosed with GERD based on the Los Angeles classification. We evaluated gastric biopsy specimens and measured serum pepsinogen levels. Interleukin polymorphisms were evaluated by polymerase chain reaction-restriction fragment length polymorphism. Of 104 patients, 56 (53.8) were endoscopically found to have GERD, with most categorized as grade A; 48 (46.2) were classified as non-GERD. Higher economic status, smoking, and a history of proton-pump inhibitor use significantly increased the risk of GERD. GERD Questionnaire scores showed a positive correlation with GERD (P < 0.001). An association was found between antral atrophic gastritis and GERD (P = 0.030), and patients with GERD more frequently had severe antral atrophy than nonerosive reflux disease (P = 0.018). We found an association between pepsinogen I/II levels and GERD (P = 0.047), but with low accuracy. IL-1β -511 TT and CT were predominant among the IL-1β -511 genotypes, and IL-8-251 AT and TT were predominant among the IL-8-251 genotypes. In conclusion, we found a high prevalence of GERD in an area with low prevalence of H. pylori infection, which could be associated with acid reflux. Smoking, history of proton-pump inhibitor use, and higher economic group significantly increased the risk of GERD. Copyright: © 2018 Miftahussurur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Actions (login required)

View Item