Phawinee Subsomwong, Phawinee Subsomwong and Muhammad Miftahussurur and Ratha Korn Vilaichone, Ratha Korn Vilaichone and Thawee Ratanachu-Ek and Rumiko Suzuki, Rumiko Suzuki and Junko Akada, Junko Akada and Tomohisa Uchida, Tomohisa Uchida and Varocha Mahachai, Varocha Mahachai and Yoshio Yamaoka, Yoshio Yamaoka (2017) Helicobacter pylori virulence genes of minor ethnic groups in North Thailand. Gut Pathogens, 9 (1). ISSN 17574749

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Abstract

Background: There are few studies analyzed concurrently the prevalence and genotypes of Helicobacter pylori infection with the ancestor origins from different ethnics, especially with including minority groups. We recruited a total of 289 patients in MaeSot, Thailand (154 Thai, 14 Thai-Chinese, 29 Karen and 92 Hmong ethnics). The virulence genes and genealogy of the strains were determined by PCR-based sequencing. Results: Based on culture and histology/immunohistochemistry, the prevalence of H. pylori infection was 54.5 (158/289). Among 152 isolates cultured, the East-Asian-type cagA was predominant genotype among strains from Hmong, Thai-Chinese and Thai (96.0 48/50, 85.7% 6/7 and 62.7% 47/75, respectively), whilst majority of strains from Karen had Western-type cagA (73.3% 11/15). Patients infected with the East-Asian-type cagA strains had significantly higher activity and intestinal metaplasia in the antrum and activity in the corpus than those with Western-type cagA (P = 0.024, 0.006 and 0.005, respectively). The multilocus sequencing typing analysis discriminated that most strains from Hmong and Thai-Chinese belonged to hspEAsia (92.0 and 85.7%, respectively), whereas strains from Karen predominantly possessed hpAsia2 (86.7%) and strains from Thai were classified into hspEAsia (45.2%) and hpAsia2 (31.1%). Conclusions: Helicobacter pylori genotypes were relatively different among ethnic groups in Thailand and were associated with the source of ancestor even living in a small rural town. Caution and careful check-up are required especially on Hmong ethnic associated with high prevalence of virulence genotypes of H. pylori. © 2017 The Author(s).

Item Type:	Article
Uncontrolled Keywords:	Helicobacter pylori, Human migration, Minor ethnics, North Thailand, Virulence factors
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
Divisions:	Artikel Ilmiah > SCOPUS INDEXED JOURNAL
Creators:	Creators NIM Phawinee Subsomwong, Phawinee Subsomwong UNSPECIFIED Muhammad Miftahussurur NIDN0029097909 Ratha Korn Vilaichone, Ratha Korn Vilaichone UNSPECIFIED Thawee Ratanachu-Ek UNSPECIFIED Rumiko Suzuki, Rumiko Suzuki UNSPECIFIED Junko Akada, Junko Akada UNSPECIFIED Tomohisa Uchida, Tomohisa Uchida UNSPECIFIED Varocha Mahachai, Varocha Mahachai UNSPECIFIED Yoshio Yamaoka, Yoshio Yamaoka UNSPECIFIED
Contributors:	Contribution Name NIDN / NIDK Author UNSPECIFIED UNSPECIFIED Author UNSPECIFIED UNSPECIFIED Author UNSPECIFIED UNSPECIFIED Author UNSPECIFIED UNSPECIFIED Author UNSPECIFIED UNSPECIFIED Author UNSPECIFIED UNSPECIFIED Author UNSPECIFIED UNSPECIFIED Author UNSPECIFIED UNSPECIFIED Author UNSPECIFIED UNSPECIFIED
Depositing User:	PPJPI
Date Deposited:	02 Mar 2022 02:35
Last Modified:	02 Mar 2022 02:35
URI:	http://repository.unair.ac.id/id/eprint/94597
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