Osamu Matsunari and Muhammad Miftahussurur and Seiji Shiota and Rumiko Suzuk and Ratha-kornVilaichone and Tomohisa Uchida and Thawee Ratanachu-ek and LotayTshering and Varocha Mahachai and YoshioYamaoka (2016) Rare Helicobacter pylori Virulence Genotypes in Bhutan. Scientific Reports, 6. ISSN 20452322

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Abstract

Both the prevalence of Helicobacter pylori infection and the incidence of gastric cancer are high in Bhutan. The high incidence of atrophic gastritis and gastric cancer suggest the phylogeographic origin of an infection with a more virulent strain of H. pylori. More than 90 of Bhutanese strains possessed the highly virulent East Asian-type CagA and all strains had the most virulent type of vacA (s1 type). More than half also had multiple repeats in East Asian-type CagA, which are rare in other countries and are reported characteristictly found in assciation with atrophic gastritis and gastric cancer consistent with Bhutanese strains having multiple H. pylori virulence factors associated with an increase in gastric cancer risk. Phylogeographic analyses showed that most Bhutanese strains belonged to the East Asian population type with some strains (17.5) sharing East Asian and Amerindian components. Only 9.5 belonged to the European type consistant with H. pylori in Bhutan representing an intermediate evolutionary stage between H. pylori from European and East Asian countries.

Item Type:	Article
Uncontrolled Keywords:	bacterial antigen; bacterial protein; cagA protein, Helicobacter pylori, adolescent; adult; aged; amino acid sequence; Bhutan; chemistry; female; genetics; genotype; Helicobacter pylori; human; male; middle aged; pathogenicity; very elderly; virulence; young adult, Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Antigens, Bacterial; Bacterial Proteins; Bhutan; Female; Genotype; Helicobacter pylori; Humans; Male; Middle Aged; Virulence; Young Adult
Subjects:	R Medicine > R Medicine (General) R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
Divisions:	Artikel Ilmiah > SCOPUS INDEXED JOURNAL
Creators:	Creators NIM Osamu Matsunari UNSPECIFIED Muhammad Miftahussurur NIDN0029097909 Seiji Shiota UNSPECIFIED Rumiko Suzuk UNSPECIFIED Ratha-kornVilaichone UNSPECIFIED Tomohisa Uchida UNSPECIFIED Thawee Ratanachu-ek UNSPECIFIED LotayTshering UNSPECIFIED Varocha Mahachai UNSPECIFIED YoshioYamaoka UNSPECIFIED
Depositing User:	PPJPI
Date Deposited:	03 Sep 2020 06:11
Last Modified:	03 Sep 2020 06:11
URI:	http://repository.unair.ac.id/id/eprint/94608
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