Gadis Meinar Sari and Kristanti Wanito Wigati and Raden Argarini (2017) The Bone remodelling profile through bone thickness analysis after salmon calcitonin administration. In: Prosiding The Role of Physiology to Increase the Quality of Life Through One Health Concept: Health Care for Human, Animals, Plants and Environment. Gadjah Mada University Press, Yogyakarta, pp. 18-29. ISBN 978-602-386-237-5

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Abstract

Bone is metabolically active organ that undergoes continuous remodelling throughtout life. Remodelling process involves resorption and formation that eventually affect the bone mass and bone density. The increasing of bone density can be affected by many factors, such as calcitonin hormone which inhibit bone resorption. Recombinan calcitonin or salmon calcitonin is proposed to have influence in bone remodelling process through inhibition of bone resorption so that the bone density increased. This study was conducted to analyzed the bone thickness after salmon calcitonin treatment. This experimental study used the post test only control group design and was carried out in Faculty of Medicine, Universitas Airlangga. Twenty eight healthy male Wistar rats (Rattus novergicus) were randomized to one combination group. The treatment group was treated for 8 weeks, and bone thickness analysis was done afterward. The trabecular thickness of femur showed significant difference between control and calcitonin treatment increases bone thickness through inhibition of bone resorption process.

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