Tjitjik Srie Tjahjandarie and Mulyadi Tanjung and Ratih Dewi Saputri and Puja Bintu Nadar and Muhammad Fajar Aldin and EvaMarliana and Anton Permad (2019) Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage. Natural Product Sciences, 25 (3). pp. 1-4. ISSN 1226-3907

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Abstract

A new isoprenylated stilbene, flavestinK (1) together with two known isoprenylated stilbenes, flavestin B (2), flavestin G (3), and two isoprenilated flavanones, 4-O-methyl-8-isoprenylnaringenin (4) and 8isoprenyl-5,7-dihydroxyflavanone (5) were isolated from the leaves of Macaranga recurvata Gage. All of the structures have been determined based on HRESIMS, 1D and 2D NMR spectral data. All of the isolated compounds were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D and WiDr). Compound 1 showed higher activity than doxorubicin against HeLa cells with IC value of 13.1 µg/mL. Keywords − Flavestin K, Stilbene, Macaranga recurvata, Cytotoxicity 50

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