Noninvasive Helicobacter pylori Diagnostic Methods in Indonesia Repository

Noninvasive Helicobacter pylori Diagnostic Methods in Indonesia

Muhammad Miftahussurur (2019) Noninvasive Helicobacter pylori Diagnostic Methods in Indonesia. Gut and Liver, 13 (6). pp. 1-7. ISSN 2005-1212

	Text (Artikel) 43. Noninvasive Helicobacter pylori Diagnostic Methods in Indonesia.pdf Download (152kB)
	Text (Similarity) Non-Invasive (1)_compressed.pdf Download (2MB)
	Text (Peer Review) peer non invasive.pdf Download (2MB)

Official URL: http://www.gutnliver.org/journal/view.html?doi=10....

Abstract

Although the prevalence of Helicobacter pylori infection in Indonesia is lower than that in other countries, H. pylori is still an essential pathogen associated with severe gastric mucosal damage and dyspeptic symptoms. Invasive diagnostic methods are not ideal due to the lack of endoscopic centers and high costs without full coverage by social insurance. Among the noninvasive methods, the urea breath test is widely available in Indonesia and has been suggested as the primary option to ensure the successful eradication of H. pylori. There has been no local validation for the urea breath test utilizing 13C or 14C. The stool antigen test is inexpensive and suitable for use in active infections before and after eradication; however, customs and habits are obstacles to delivering fresh stool on time. Only polyclonal antibodies and qualitative stool antigen test kits with low sensitivity are available. Serology is a widely validated method and has good accuracy, but it cannot distinguish between active and inactive infections. According to our observations, serology is the main choice of experts and patients, as it is simple, inexpensive and widely known. The urine test is an alternative for reducing costs and endoscopic workload, with high accuracy but low sensitivity. Further studies are necessary to prove the validity of the urine test to be used throughout Indonesia, especially in areas with a low prevalence of H. pylori infection. In conclusion, the validated urea breath test and the stool antigen test are considered noninvasive practical approaches for the detection of H. pylori infection in Indonesia, with serological and urine tests as alternatives.

Item Type:

Article

Uncontrolled Keywords:

Noninvasive, Helicobacter pylori, Urea breath test, Stool antigen test, Serology

Subjects:

R Medicine > R Medicine (General)
R Medicine > RC Internal medicine

Divisions:

01. Fakultas Kedokteran > Ilmu Penyakit Dalam

Creators: