Ni Made Mertaniasih (2010) Resistance Mechanism of Mycobacterium Tuberculosis to Anti-Tuberculosis Drugs nad Multidrug Resistant Tuberculosis. Majalah Kedokteran Respirasi, 1 (12). pp. 8-12. ISSN 0216-5899

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Abstract

The problem of multidrug resistance is worsening in 2008; WHO's global reposrt on ati-tuberculosis drug resistance ever recorded the highest level of multidrug resistant tuberculosis (MDR-TB) in a general population, with an estimated half a million cases occuring globally. Understanding the emergence and transmission of drug resistant tuberculosis urge to develop and implement the strategic plans on prevention and control drug resistant tuberculosis in line with stop TB partnership's Global plan to Stop TB 2006-2015. Progress in understanding of the drug action and resistance is the important key to develop tuberculosis management program, i.e.: diagnostic strategies and treatment management. The aquisition of resistance on Mycobacterium tuberculosis to anti-tuberculosis drugs derives from randomized and spontaneous chromosomal mutation naturally events, reflects the stepwise accumulation of indivudal mutations in several independent genes; and crucial problems on inadequate traetment create the favorable conditions for the selection of drug resistant Mycobacterium tuberculosis, which develop acquired anti-TB drug resistance and multidrug resistant tuberculosis (MDR-TB); and the transmission to contact persons will multiply primary resistance in a population.

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