Dina Warda Rosadiani (2015) Pengaruh Konsentrasi Natrium Alginat Terhadap Karakteristik Fisik, Viabilitas Dan Aktivitas Antikanker Mikropartikel Kombinasi Probiotik Dan Pasta Tomat. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The aim of this research was to investigate effect of natrium alginate concentration in physical characteristic, viabilility, and anticanceractivity of probiotic-tomato paste microparticle. Natrium alginate concentration 2,5%, 3%, and 3,5% were used for maked microparticle in this study by extrusion method, then dried by freeze dry method. Resulting microparticle were characterised in terms of physical characteristic (morphology, particle size, and MC), viability of probiotic, and anticancer activity. The particle size of microparticle increase with increasing natrium alginate concentration, but MC of microparticle decrease with increasing natrium alginate concentration. The result of viability tests show that increasing natrium alginate concentration will increase viability of Lactobacillus acidophilus in microparticle under extrusion and freeze dry process and under intestin condition, the highest viability was obtained from formula III with 95,58% viability that significant diffferent with formula I (p<0,05), but didnot have significant different with formula II (p>0,05). And then, the result for anticancer activity show that increasing natrium alginate concentration was havenot significant different with other formula (p>0,05), the highest activity was obtained from formula III with 230,79±70,53 ppm.

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