ARDIANA PUTRI KUSUMANINGTYAS, 050112425 (2011) KARAKTERISTIK DISPERSI PADAT ALOPURINOL-NIKOTINAMID. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Allopurinol is a commonly used drug in the treatment of chronic gout or hyperuricemia. One of the major problems with also is that, it is practically insoluble with water, which results in poor bioavailability after oral administration. In the present study, solid dispersions of allopurinol were prepared by solvent evaporation method in the ratio 1:1. Prepared solid dispersions were characterized in the liquid state by phase solubility studies and in the solid state by infrared spectrophotometry, X-ray diffract ometry (XRD),Differential Thermal Analysis (DTA) and Scanning Microscope Electron (SEM).FTIR analysis indicates the absence of any interaction between allopurinol and nicotinamide. Characterization with XRD showed the signi ficant decrease in cristalinity of pure drug present in solid dispersions or physical mixture. DTA studies revealed that there was a decrease of allopurinol melting point SEM photomicrograf of solid dispersions showed that solvent evaporation method were effective in producing highly homogeneous partially solid dispersions systems.

Item Type:	Thesis (Skripsi)
Additional Information:	KKB KK FF 241 11 Kus k
Uncontrolled Keywords:	NIKOTINAMID
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	05. Fakultas Farmasi > Farmastika
Creators:	Creators NIM ARDIANA PUTRI KUSUMANINGTYAS, 050112425 UNSPECIFIED
Contributors:	Contribution Name NIDN / NIDK Thesis advisor Achmad Radjaram UNSPECIFIED Thesis advisor Sugiyartono, Drs. H. , Apt., MS UNSPECIFIED
Depositing User:	Dwi Marina
Date Deposited:	26 Jan 2012 12:00
Last Modified:	05 Jul 2017 20:48
URI:	http://repository.unair.ac.id/id/eprint/9529
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