Andang Miatmoko and Ricky Hartono Salim and Siti Maria Zahro and Febri Annuryanti and Retno Sari and Esti Hendradi (2019) Dual Loading Of Primaquine And Chloroquine Into Liposome. European Pharmaceutical Journal, 6 (2). pp. 18-25. ISSN 2453-6725

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Abstract

Primaquine (PQ) has long been recognized as the only effective drug in the treatment of hepatic stage malaria. However, severe toxicity limits its therapeutical application. Combining PQ with chloroquine (CQ) has been reported as enhancing the former’s efficacy, while simultaneously reducing its toxicity. In this study, the optimal conditions for encapsulating PQ-CQ in liposome, including incubation time, temperature and drug to lipid ratio, were identified. Furthermore, the effect of the loading combination of these two drugs on liposomal characteristics and the drug released from liposome was evaluated. Liposome is composed of HSPC, cholesterol and DSPE-mPEG2000 at a molar ratio of 55:40:5 and the drugs were loaded by means of the transmembrane pH gradient method. The particle size, ζ-potential and drug encapsulation efficiency were subsequently evaluated. The results showed that all liposome was produced with a similar particle size and ζ-potential. PQ and CQ could be optimally loaded into liposome by incubating the mixtures at 60oC for 20 minutes at a respective drug to lipid ratio of 1:3 for PQ and CQ. However,compared to single drug loading, dual-loading of PQ+CQ into liposome resulted in lower drug encapsulation and slower drug release. In conclusion, PQ and CQ can be jointly loaded into liposome with differing profiles of encapsulation and drug release.

Item Type:	Article
Uncontrolled Keywords:	Dual loading, primaquine, chloroquine, liposome, release
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica
Divisions:	05. Fakultas Farmasi Artikel Ilmiah > SCOPUS INDEXED JOURNAL
Creators:	Creators NIM Andang Miatmoko NIDN0002108503 Ricky Hartono Salim NIM051411131197 Siti Maria Zahro NIM051411131170 Febri Annuryanti NIDN0012128401 Retno Sari NIDN0008106303 Esti Hendradi NIDN0014115703
Depositing User:	Mr M. Fuad Sofyan
Date Deposited:	12 May 2020 02:45
Last Modified:	03 Mar 2021 13:17
URI:	http://repository.unair.ac.id/id/eprint/95303
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