Retno Sari and M. Agus Syamsur Rijal and Dian Maya Sari and Ima Dewi Ruliyana (2012) Physical Characterization And In Vitro Release Study On Theophylline-Chitosan Microparticles (Effect On Crosslinking Time And Method Of Preparation). PharmaScientia, 1 (1). pp. 11-15. ISSN 2302-0725

	Text (FULLTEXT) C-17.pdf Download (963kB)
	Text (PEER REVIEW) C-17-Validasi.pdf Download (1MB)
	Text (KORESPONDENSI) Klarifikasi C-17 bukti Korespondensi Pharma Scientia Retno Sari.pdf Download (269kB)

Abstract

Microparticles of theophylline using chitosan as polymer and tripolyphosphate as crosslinker were prepared by ionic gelation (IG) methods. In this study, microparticles were prepared by two different of IG methods : orifice ionic gelation (OIG) and emulsification ionic gelation (EIG) with different crosslinking time. The obtained microparticles were evaluated for its particles size, entrapment efficiency and in vitro release in CO2 free water. The particle size of microparticles were in the range of 987 – 1687 µm. Microparticles prepared by OIG had larger size than microparticles prepared by EIG and the size grew larger as crosslinking time longer. Both methods with different crosslinking time resulted similar and relatively high entrapment efficiency (± 60%).The release profile indicated that microparticles prepared by OIG had more retarded release compare to EIG’s particles.. This result will be further studied to decrease the size in nanoparticles range by developing the preparation methods

Actions (login required)

View Item