GUNAWAN WIBISONO, 050810163 (2011) POLA PENGGUNAAN ANTIBIOTIKA PADA PASIEN STROKE PERDARAHAN DENGAN INFEKSI Penelitian Dilakukan Di Instalasi Rawat Inap Ilmu Penyakit Saraf RSUD. Dr. Soetomo Surabaya. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

BACKGROUND Haemorrhagic stroke is disorder in cranial which occurs cracked blood-vessels. The most risk factor is hypertension, that makes arterials in cranial weaken and very easy to be cracked. Also, stroke haemorrhage decreases physiology function that can be effect to immune function. Lower immune function can makes body infected pathogen microbials very easy, that makes antibiotics need to be given accurate to the patient, to reach optimal therapy dan decrease resistency of pathogen microbials in patients. OBJECTIVES . The purpose of this study was to analyze antibiotics profile, dosage regimens, and route administrations, also analyze the connection within antibiotics therapy and laboratory and clinical data. SUBJECS AND METHODS A retrospective methods with descriptive analysis was performed in 30 patien ts which obtained from January 2010 up to December 2010. Patients is who get final diagnose haemorrhagic stroke and have infection signs with antibiotics as medicine for their therapy. RESULTS The result showed that 28 patient r eceived empiric antibiotic, which the most choosen as empiric antibiotics is ceftria xone (73,33%). Route of administrations is Intravenous route which can get maximum plasma concentration quickly with 100% bioavailibility. Dosage regimentation is adequate with textbook and guidelines but there is patients need to get addjusment dose for their therapy because they have abnormal result of creatinin serum. Definitive antibiotics just been given in one patient, because just one patient do microbiology test with dosage regimentation is like textbook and route of administration is Intravenous. CONCLUSIONS. Choosing antibiotics for patients must be exactly right is done for assure optimal therapetic for patients. Election of empiric antibiotics is equal with microbial map in Instalation of Neurology, beside that for definitive antibiotics is elected right based on microbiology test that can decrease resistancy occurs in patients.

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