Esti Rohani and Yetti Hernaningsih and Suprapto Ma'at and Ummi Maimunah (2013) Immature PLatelet Fraction (IPF) dan Trombopoietin di Sirosis Hati. Indonesian Journal of Clinical Pathology and Medical Laboratory, 19 (2). pp. 112-118. ISSN 0854-4263

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Abstract

Liver cirrhosis remains a major clinical problem worldwide when associated with significant morbidity and mortality due to its complications. The presence of liver cirrhosis state affects the production of TPO influencing the process of thrombopoiesis. The thrombopoiesis activity can be described by the Immature Platelet Fraction (IPF) value which is young platelets. The immature Platelet fraction value increases when platelet production enhances as well, on the contrary when the production declines, the IPF value is also decreased. This study was performed by cross-sectional method using 31 subject samples suffering from liver cirrhosis, consisting of Child Pugh score class A 2 samples (6.4%), Child Pugh score class B 9 samples (29%) and Child Pugh score class C 20 samples (64.6%). The examination of TPO levels was done by ELISA method using Humans TPO QuantikineR, the IPF value was examined using Sysmex XE-2100 Hematology Analyzer. The thrombopoietin serum levels in the samples ranged from 23.5 to 96.6 pg/mL with a mean of 45.1pg/mL. The immature Platelet Fraction values varied from 1.7% to 19.1% with a mean of 6.7%. From the statistical analysis, the levels of TPO and IPF at various degrees of the disease severity were not significantly different. There was no significant correlation between the TPO level and IPF value, r = 0.038, p = 0.837. There was no significant difference between the TPO level and the IPF value in the splenomegaly and nonsplenomegaly state. In conclusion, based on this study no significant correlation was found between the IPF value with thrombopoietin serum levels, as well as the IPF and thrombopoietin levels, and there was no association with the disease severity.

Item Type:	Article
Uncontrolled Keywords:	Thrombopoietin, IPF, liver cirrhosis
Subjects:	R Medicine > R Medicine (General) R Medicine > RB Pathology
Divisions:	01. Fakultas Kedokteran > Patologi Klinik
Creators:	Creators NIM Esti Rohani UNSPECIFIED Yetti Hernaningsih NIDN0020127307 Suprapto Ma'at UNSPECIFIED Ummi Maimunah NIDN8896900016
Depositing User:	arys fk
Date Deposited:	12 May 2020 01:04
Last Modified:	12 May 2020 01:04
URI:	http://repository.unair.ac.id/id/eprint/95376
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