Tsana Nadira Susanto and Yetti Hernaningsih and I Dewa Gede Ugrasena (2018) Peran Profil Terhadap Luaran Kemoterapi Fase Induksi PAsien Leukemia Limfoblastik Akut Anak. Jurnal Kesehatan Soetomo, 5 (1). pp. 1-5. ISSN 2407-2486

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Abstract

Background Acute lymphoblastic leukemia is a common malignancy that occurs mostly in children with various manifestations of symptoms. Acute lymphoblastic leukemia is doagnosed when ≥25% lymphoblast were present in the bone marrow aspirate. Treatment that can potentially work to eradicate malignancy is by chemotherapy which consists of four phase including induction, consolidation, maintenance, and CNS adjuvant therapy. But the successful outcome depends on many factors, one of which is whethet the patient have or have not reach remission after chemotherapy. Objective Analyze the association between clinical and laboratory findings as the parameter of outcomes in acute lymphoblastic leukemia patients after induction of chemotherapy. Metode A cross sectional study of observational analysis with the total sample of 77 children that were diagnosed with acute lymphoblastic leukemia, This experiment used secondary data taken from medical record in Pediatric Hematology-Oncology Policlinic of RSUD Dr. Soetomo during 2014-2016. Result The average age at diagnosis was 5,35 ± 2,9 with males predominant (54,5%). The remission induction rate was 85,7% with complete remission, 10,4% with partial remission, and 3,9% with remission failure. The result of analysis of regression logistic multinominal was no significant result between laboratory or clinical findings with outcomes of induction chemotherapy in acute lymphoblastic leukemia patients (Anemia p=0,559, Thrombocytopenia p=0,232, Leukocytosis p=0,211, Leukopenia p=0,288, Lymphocytosis p=0,559, Hepatomegaly p=0,127, Splenomegaly p=0,081, Lymphadenopathy p=0,228, Meningeal Syndrome p=0,757, and Bleeding p=0,959). Conclusion There is no parameter found whether laboratory or clinical findings that significantly associated with outcomes of induction chemotherapy in acute lymphoblastic leukemia.

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