Dimas Visa Aditya and Tarmono Djojodimedjo and Doddy M. Soebadi (2019) Effect of Vitamin E (α-Tocopherol) Administration on Sperm Motility and Morphology of Sprague Dawley Strain Rats After Cisplatin Treatment. Indonesian Journal of Urology, 26 (1). pp. 53-62. ISSN 0853-442X

	Text (Peer Review) Effect of Vitamin E.pdf Download (2MB)
	Text (Artikel) Effect of Vitamin E (α-Tocopherol) Administration on Sperm Motility and Morphology of Sprague Dawley Strain Rats After Cisplatin Treatment.pdf Download (14MB)
	Text (Similarity) Effect of Vitamin E (α-Tocopherol) Administration on Sperm Motility and Morphology of Sprague Dawley Strain Rats After Cisplatin Treatment_compressed.pdf Download (2MB)

Abstract

Objective: To evaluate the protective effects of vitamin E α-tocopherol isomer against the toxicity of cisplatin on sperm motility and morphology in Sprague Dawley rats. Material & Methods: Twenty-four rats were grouped into four groups (n=6). The control group (CN) was injected with normal saline, second group (CP) was injected with cisplatin, the third group (P1) was injected with cisplatin and vitamin E 50 mg/kgBW for 7 weeks P.O, the fourth group (P2) was injected with cisplatin and vitamin E 200 mg/kgBW for 7 weeks P.O. Vitamin E was given from 3 weeks before cisplatin injection and 4 weeks following cisplatin injection. At 7th week, all the samples were undergoing bilateral orchidectomy. Vitamin E that being used in this study was α-tocopherol isomer. Results: Cisplatin decreased motility and morphology of spermatozoa significantly against controls. Vitamin E 50 mg/kgBW and 200 mg/kgBW significantly increased motility of spermatozoa (p<0.05) compared to those in the cisplatin group only. Vitamin E 50 mg/kgBW, and 200 mg/kgBW did not have a significant difference in spermatozoa motility compare to control groups. Vitamin E 50 mg/kgBW and 200 mg/kgBW could increase the spermatozoa morphology significantly compare to those cisplatin only group. Vitamin E 50 mg/kgBW, and 200 mg/kgBW did not have a significant difference in spermatozoa morphology compared to control groups. Conclusion: α-tocopherol 50 mg/kgBW and 200 mg/kgBW provided a same protective effect against spermatozoa damage especially in motility and morphology aspect due to cisplatin exposure. Therefore, in this study it was more recommended to use α-tocopherol in 50 mg/kgBW dose than 200 mg/kgBW.

Actions (login required)

View Item