Maulidina Hapsari and Tutiek Purwanti and Noorma Rosita (2012) Penetrasi Natrium Diklofenak Sistem Niosom Span 20-Kolesterol Dalam Basis Gel HPMC 4000. PharmaScientia, 2 (1). pp. 1-12. ISSN 2302-0725

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Abstract

The present study was designed to determine characteristic and penetration of diclofenac sodium in niosomal system which had been prepared in hidroxypropylmethyl cellulosa (HPMC) 4000 gel. The compositions of niosomal system was diclofenac sodium, Span 20, and cholesterol 1:6:6. There were two formulas: Formula I was diclofenac sodium in HPMC 4000 gel without niosomal system and formula II was diclofenac sodium in niosomal system that was prepared in HPMC 4000 gel. The result showed that niosomal system had effect on color and odor. Data analysis showed that pH of formula I was 6,30±0,04 and formula II was 6,94±0,03. Spread diameter of zero load for formula I was 6,17±0,06 and formula II was 7,60±0,20. The penetration rate of diclofenac sodium from formula I was 1,4036±0,0696 μg/cm2/min and formula II was 1,1180±0,1111 μg/cm2/min. Membrane permeability for formula I was 1,3387.10-4±0,0677.10-4 cm/min and formula II was 1,0847.10-4±0,1069.10-4 cm/min. The results were analyzed statistically using independent sample t-test with degree of freedom 4 and degree of confident 95%. Research result revealed that the penetration rate and membrane permeability of diclofenac sodium in HPMC 4000 gel with niosomal system were slower than diclofenac sodium without niosomal system.

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