SAIFUL HAKIM, 050710250 (2011) KARAKTERISASI ORALLY DISINTEGRATING TABLET PIROKSIKAM DENGAN PENGIKAT GELATIN 1% DAN 2% MENGGUNAKAN SUPERDISINTEGRAN CMC-Ca 2,5% (Dibuat Dengan Metode Freeze Drying). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Piroxicam is an effective cyclo - oxygenase inhibitor wit h anti - inflamatory and analgesic properties. Orally disint egrating tablets of piroxicam were prepared by freeze drying method using mannitol based excipient . These tablets contains CMC - Ca 2,5% as superdisintegran, gelatine 1% and 2% as binder. Orally disintegrating tablets were characterized by differential therm al analysis (DTA), powder x - ray diffractometry (PXRD) and scanning electron microscopy (SEM). The characteristics were compared between single compound, physical mixture and freeze dr i ed ODT. The DTA and PXRD study indicate d that compared to physical mixtu re there was a decrease in degree of cristalinity of piroxicam in freeze dr i ed orally disintegrating tablets. DTA and PXRD data also demonstrated that increasing the con c entration of gelatin decreas ed the degree of cristalinity of piroxicam in the freeze d r i ed orally disintegrating tablets. C haracterization with Scanning E lectron Mic roscope show ed that tablet s made by fr reeze d rying was porous. Porous structure of orally disintegrating tablets causes quick penetration of saliva in the pores when placed in o ral cavity lead to improve disintegrit ion of the tablets

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