AMELIA DWI SULISTIOWATI, 050710175 (2011) KARAKTERISASI SOLID LIPID NANOPARTICLES (SLN) - NATRIUM DIKLOFENAK - SETIL ALKOHOL DENGAN BERBAGAI KADAR TWEEN 80 (8%, 10%, 12%). Skripsi thesis, UNIVERSITAS AIRLANGGA.

Preview	Text (ABSTRAK) gdlhub-gdl-s1-2012-sulistiowa-22286-ff2651-k.pdf Download (336kB) | Preview
	Text (FULLTEXT) gdlhub-gdl-s1-2012-sulistiowa-18650-ff2651-k.pdf Restricted to Registered users only Download (2MB) | Request a copy

Abstract

Diclofenac sodium was known as an eff ective NSAIDs to relieve joint pain. There are some disadvantages in severa l drug administrations (oral, rectal, parenteral) of diclofenac sodium, so th e topically route has been chosen as alternative drug administrations. Recently, solid lipid nanoparticles (SLN) was greatly investigated as a new drug deliver y system. SLN had several benefits as a topical drug carrier. The ai m of this study was to observe the characteristic of SLN-diclofenac sodium-cetyl alcohol which was formulated by different concentration of Tween 80 (8%, 10%, 12%) and determined SLN with best characteristic at certain concentration of Tween 80. SLN was prepared using high shear homogenization method at 25000 rpm for 8 minutes. The result showed SLN with Tween 80 10% had the best characteristic. SLN with Tween 80 10% had higher pe rcent drugs entrapment (mean 91,36%) and smaller size (mean 11,3 nm) than others

Actions (login required)

View Item