IRNI FAHMAWATI DEWI, 050710097 (2011) PENGARUH CMC-Ca TERHADAP MUTU FISIK DAN DISOLUSI ORALLY DISINTEGRATING TABLET PIROKSIKAM DENGAN PENGIKAT GELATIN 2% DAN BASIS MANITOL (Dibuat dengan Metode Freeze Drying). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Orally Disintegrating Tablet (ODT), usually prepared using freeze drying method are becoming popular drug formula tions for patients who have difficulties in swallowing oral dosage form. The influence of CMC-Ca on physical characteristics and dissolution Orally Di sintegrating Tablet piroxicam with 2% gelatin as a binder and base manitol was investigated. Piroxicam, as the API (active pharmaceutical ingredient), was dispersed in manitol, CMC-Ca and gelatin, prior lyophilization. Physical characteristics of the tablets, including tablet hardness, friability, disintegration time, and disso lution profile were determined. Results showed that tablet containing gelatin 2% and CMC-Ca 2,5% has better mechanical strength compared to those tablets prepared w ithout CMC-Ca and tablet with CMC-Ca 7,5%.

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