Marcellino Rudyanto and Juni Ekowati and Tri Widiandani and Toshio Honda (2014) Synthesis And Brine Shrimp Lethality Test of Some Benzoxazine and Aminomethyl Derivatives of Eugenol. International Journal of Pharmacy Pharmaceutical Sciences, 6 (2). pp. 465-467. ISSN 0975-1491

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Abstract

The specific objective of this research is to synthesize novel 1,3-benzoxazine and aminomethyl compounds from eugenol and study their biological activity. Eugenol was reacted with formaldehyde and primary amines following Mannich reactions. The obtained 1,3-benzoxazine compounds were then hydrolyzed to give the aminomethyl derivatives. All the obtained 1,3-benzoxazine and aminomethyl compounds were tested for biological activity using brine shrimp lethality test (BST). It was found that 6-allyl-8-methoxy-3-phenyl-3,4-dihydro-2H-benzo[e][1,3]oxazine, 6-allyl-3-benzyl8-methoxy-3,4-dihydro-2H-benzo[e][1,3]oxazine,4-allyl-2-methoxy-6-phenylaminomethylphenol, 4-allyl-2-(benzylaminomethyl)-6-methoxyphenol, and 4-allyl-2-{[(furan-2-ylmethyl)-amino]-methyl}-6-methoxyphenol show toxicity on BST, and therefore potential to be further studied for their bioactivity.

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