Galih Satrio Putra and Anita Puspa Widiyana and Luthfi Ahmad Muchlashi and Melanny Ika Sulistyowati and Juni Ekowati and Tutuk Budiati (2017) The Influence of Ratio Pyridine and Triethylamine Catalysts on Synthesis 2-Phenyl-Benzo [D][1, 3] Oxazine-4-On Derivatives. Journal of Chemical and Pharmaceutical Research, 9 (8). pp. 73-80. ISSN 0975-7384

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Abstract

The aim of this research was to compare the effect of pyridine and triethylamine catalyst ratios on the synthesis of 2-phenyl-benzo(d)[1,3] oxazine-4-one derivatives. The catalysts used were triethylene amine (100%), pyridine: triethylamine (1: 4 mol); Pyridine: triethylamine (1: 1 mol) and pyridine (100%). Using pyridine (100%) as a catalyst could increase the percentage of the synthesis of 2-phenyl-benzo[d][1,3] oxazine-4-one derivatives to 2 times greater than pyridine: triethylamine (1: 4 mol) as a catalyst. Using pyridine (100%) as a catalyst in the synthesis of 2-phenyl-benzo[d] [1,3]oxazine-4-one derivatives were more effective and efficient by obtaining the following results we obtained 80% for 2-phenyl-4Hbenzo[1,3]oxazin-4-one and 86% for 2-(3,4-dichlorophenyl)-4H-benzo[1,3]oxazin-4-one and 82% for 2-(2,4-dichlorophenyl)-4H-benzo[1,3]oxazin-4-one and 46% for 2-(4-nitrophenyl)-4H-benzo[1,3]oxazin-4-one.

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