ABHIMATA PARAMANANDANA, 050710048 (2011) UJI AKTIVITAS ANTIINFLAMASI ASAM p- METOKSISINAMAT (0,34%) SISTEM SOLID LIPID NANOPARTICLES DENGAN BASIS HPC-H. Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Kencur ( Kaempferia galanga ) was known as an traditiona l herb to relieve pains and aches. p- Methoxycinnamic acid was proposed to have an anti-inflamatory activity. Solid lipid nanoparticles (SLN) was greatly investigated recently as a new drug delivery system. SLN had severa l benefits as a topical drug carrier. The aim of this study was to observe the area under curve (AUC) each formula with different system using the same gel base (HPC-H). Three different system of p- methoxycinnamic acid was made into topical preparation; p- methoxycinnamic acid with propylene glycol (FI), p- methoxycinnamic acid containing cetyl alchohol, tween 80, propylene glycol w ithout been made to solid lipid nanoparticle system (FII), p- methoxycinnamic acid containing the same component thats loaded to solid lipid nanoparticle system (FIII), 1% sodium diclofenac as positive contro l (K+) and base gel HPC-H as the negative control (K-). All the five formulation were screened for their anti-inflamatory activity using carragenan induced paw edema mode ls respectively. In anti-inflamatory activity, FI, FII and FIII has showed signi ficant inhibition of carrageenan induced rat paw edema compared to control gr oup in which only gel base HPC-H was used. The anti-inflamatory activity of FI and FIII were compareable with 1,0% sodium diclofenac gel which was used as standard. The result of the present study further confirm that p- methoxycinnamic acid loaded solid lipid nanoparticles (SLN) has no significant differences with p methoxycinnamic acid in base gel with area unde r curve as the parameter study.
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK FF 293 11 Par u | |||||||||
| Uncontrolled Keywords: | METOKSISINAMAT | |||||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica | |||||||||
| Divisions: | 05. Fakultas Farmasi > Farmastika | |||||||||
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| Depositing User: | Dwi Marina | |||||||||
| Date Deposited: | 26 Jan 2012 12:00 | |||||||||
| Last Modified: | 05 Jul 2017 22:55 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/9582 | |||||||||
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