JOHAN PRATAMA RAHARDJO, 050710141 (2011) PENGARUH PENINGKATAN KADAR HPMC K4M TERHADAP MUTU FISIK, KARAKTERISIK FLOATING, DAN PELEPASAN TABLET FLOATING LEPAS LAMBAT RANITIDIN HCL DENGAN METODE GRANULASI BASAH. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The main purpose of this work was to prepare floating matrix drug delivery system of Ranitidine HCl. Floating matrix tablets of Ranitidine HCl were developed to prolong gastric residence time and increase its bioavailability. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. Floating matrix tablets containing 120 mg Ranitidine HCl were developed using effe rvescent salts and hydrophilic polymer. The tablets were prepared by wet granulation technique, using polymer such as hydroxypropyl methylcellulose (HPMC K4 M). Sodium bicarbonate incorporated as a gas-generating agent. The formulation was optimized on the basis of acceptable tablet properties, physical characteristics, floating lag time, total duration of floating and in vitro drug release. Four different formulas of ranitidine HCl were prepared by wet granulation using different concentration of hydroxypropyl methylcelluloce K4M, which first formula (FI) without hydroxypropyl methylcelluloce K4M. The FII, FIII, and FIV used hydroxypropyl methylcelluloce K4M 20% ,24%, and 28% respectively. The prepared tablets were evaluated on their physical characteristics, floating characteristics and drug release . The dissolution test was performed using 900 ml of 0,1 N hydrochloric acid, at 37 ± 0,5°C and 50 rpm. The result showed that the kinetic release of FII and FIII followed Higuchi’s model, and FIV followed first order. The release mechanism dominated by matrix porous.

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