ZAINITA MARDINI, 050710301 (2011) PENGARUH L- ARGININ DALAM DISPERSI PADAT ALOPURINOL � PVP K-30 TERHADAP LAJU DISOLUSI ALOPURINOL. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Allopurinol is a commonly used drug in the treatment of chronic gout or hyperuricemia. Alopurinol is practically insoluble in water, but it has good penetration on the biological membrane, so that dissolution rate is the rate limiting step of drug absorption process and de termine poor bioavability after oral administration. Solid dispersion could enha nce dissolution rate of alopurinol. PVP K-30 is one of matrix that usually used in solid di spersion. Combination between PVP K-30 as matrix and L-Arginin could enhance dissolution rate of allopurinol with ion interaction between allopurinol-L-Arginin to be a soluble substance easily in water. The aim of this study was to enhance dissolution rate of alopurinol preparing into solid dispersion of PVP K-30 combination with the addition of LArginin could increase drug wettability, a nd happen ion interaction between allopurinol-L-Arginin when it contact w ith dissolution medium so that the dissolution rate of allopu rinol could increase. Soli d dispersion system were prepared by solvent method with ratio a llopurinol-PVP K-30-L- Arginin (5:5:6,4) so is called ternary solid dispersion, a llopurinol-PVP K-30 (5:5) and allopurinol- L-Arginin (5:6,4) so is ca lled binary solid dispersion. That is compared with allopurinol substance, bina ry physical mixture and ternary physical mixture. Evaluation were carried out by dissolution test of solid dispersion of alopurinol- PVP K-30-L-Arginin, physical mixtur es and alopurinol substance. The result showed that solid disper sion of alopurinol-PVP K-30-L-Arginin (5:5:6,4) give the highest dissolution rate compared to the physical mixture and alopurinol substance.

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