RAESHA HAMID, 050710220 (2011) STUDI PENGGUNAAN ANTIBIOTIKA PADA PASIEN TUMOR OTAK DENGAN TREPANASI-EKSISI TUMOR Penelitian Dilakukan di IRNA Ilmu Penyakit Saraf RSUD Dr. Soetomo Surabaya. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background. Brain tumor is the leading cause of death after stroke in a group of neurological diseas e. Therapy to address the increasing tumor mass is by means of surgical excision using tr epanation procedure. A significant problem in the trepanation procedure is infection, with risk of 2-3%. Purpose. This study was designed to examine the use of antibiotic including its type, dose, route, duration of administration, and frequency in patients with brain tumors of which tr epanation-excision of the tumor performed. Result. This study was conducted retrospecti vely from period of January to December 2010. In this study, we studi ed the clinical data of 30 patients consisted of 17 males (57%) and 13 female s (43%) with an age range of mostly 21-60 years (67%). Prophylactic antibiotics that were frequently used were ceftriaxone (60%), fosfomycin (37%), and ceftazidime (3%). The use of antibiotic therapy including ceftriaxone (47%), fosfomyci n (28%), meropenem (7%), levofloxacin (5%), cefixime (3%), ceftazidime, amikacin, cefpirome, clindamycin, cefoperazone-sulbactam (2%) by intravenous (i.v.) route. The treatment duration of antibiotic therapy high ly depends on the infection and severity of clinical symptoms that arise as we ll as the presence or absence of complications illnesses or diseases. The use of drugs can cause drug related problems (DRP) and in this study, DRP is observed in patient 8 and 19 due to inappropriate indication of antibiotic, in patient 9 and 30 due to dose conformity (overdose), and also interaction with other drugs (in this case, dexamethasone-phenytoin and ranitidine-phenytoin). Conclusion. The selection of prophylaxis and therapy antibiotic that commonly use properly is ceftriaxone an d fosfomycin intravenously. Dose in 28 patients was given accordingly to literature. Definitive antibiotic therapy given to patients was according to t he culture results. Drug Rela ted Problems (DRP) that occurs is generally because of inappropr iate indication, dose conformity, and interaction with other drugs.

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