AMANDA RAMADANI, 050710249 (2011) KARAKTERISASI SEDIAAN DAN UJI PELEPASAN NATRIUM DIKLOFENAK DENGAN SISTEM MIKROEMULSI W/O DARI BASIS GEL CARBOMER 940 (Mikroemulsi W/O dengan Surfaktan Span 80-Tween 80 : Kosurfaktan Etanol 96% = 6:1). Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
The aim of this study was to observe the characterization dosage form and release of diclofenac sodi um with microemulsion w/o system from carbomer 940 gel base. Microemulsion contained ratio surfactant span80-tween80 and cosurfactant etanol 96% 6:1. Diclofenac s odium gel with emulsion was used as control. The evaluation included organol eptic, pH, spreadability, and also diclofenac sodium release test from gel base of each formula. Data from pH test, spreadability, and spread diameter of zero load, were evaluated based on independent sample t-test. The result showed that microemulsi on system in gel base (formula I) showed thicker consistency than emulsion in gel base (formula II). Microemulsion in base gel Carbomer 940 didn’t have effect on pH but it had effect on spreadability and spread diameter of zero load. Data analyze showed that pH of formula I was 6,00±0,02 and formula II was 5,97±0,03. Spreadability of formula I was 0,0120 ± 0,0020 and formula II was 0,0480 ± 0,0100. Spread diameter of zero load for formula I was 4,97 ± 0,50 and formula II was 11,30 ± 1,05. Dissolution test was carried out with apparatus 5-paddle overdisk in phosphate buffer 7,4 ± 0,05, temperature 32oC, 100 rpm . The result of diclofenac sodium realease study is flux. Flux is the cumulative amount of diclofenac sodium release per cm2 per minute1/2. The rate of diclofenac sodium release in formula I (37,1185±0,2828 μ g/cm2/menit1/2) and formula II (59,6518±1,89872828 μ g/cm2/menit1/2). It was analyzed by statistic programmed of SPSS using independent sample t-test with degree of confident 95% ( α =0,05). The result show that there was a significant difference between each formula
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK FF 304 11 Ram k | |||||||||
| Uncontrolled Keywords: | carbomer | |||||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica | |||||||||
| Divisions: | 05. Fakultas Farmasi > Farmastika | |||||||||
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| Depositing User: | Dwi Marina | |||||||||
| Date Deposited: | 26 Jan 2012 12:00 | |||||||||
| Last Modified: | 18 Jul 2017 18:14 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/9590 | |||||||||
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