DINI DWI ALFENIA, 050610173 (2011) TOKSISITAS SUBKRONIK CAMPURAN EKSTRAK ETANOL 96% HERBA SAMBILOTO (Andrographis paniculata Nees) dan EKSTRAK ETANOL 96% RIMPANG TEMU KUNCI (Boesenbergia pandurata Roxb) PADA TIKUS PUTIH JANTAN. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Subchronic toxicity assay of sambiloto herbs ( Andrographis paniculata Nees) ethanolic extract an d temukunci rhizome ( Boesenbergia pandurata Roxb) ethanolic extract mixture on male albino rats has been done. This research aimed to evaluate preclinical symptoms that perhaps occur due to the giving of the mixture, single dosage orally on 24 hours within 90 days observation. Male rats used for this research, which are divided into 4 groups. Group I was untreated group with CMC- Na 0.5%, and the rest are treated groups. Group II wa s given sample with 2.70 mg andrographolide/kg BW and 2.70 mg pinostrobin/kg BW dosage. Then, succesively group III with 8.10 mg andrographolide/ kg BW and 8.10 mg pinostrobin/kg BW dosage, group IV with 13.50 mg andr ographolide/kg BW and 13.50 mg pinostrobin/kg BW dosage. Data was analyzed by One-Way ANOVA test with α = 0.05 and Kruskall Wallis test with α = 0.05. No mortality, o phthalmic abnormalities or treatment-re;ated clinical signs were identified during the studied. On the basis data analysis result having been performed all dosage gr oups (group II with 2.70 mg andrographolide/kg BW and 2.70 mg pinostrobin/kg BW dosage, group III with 8.10 mg andrographolide/kg BW and 8.10 mg pinostrobin/ kg BW, group IV with 13.50 mg andrographolide/kg BW and 13.50 mg pinostrobin/kg BW dosage) didn’t cause significant hematological change and neither did parameters of c linical chemistry.

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