PRAMUDITA RIWANTI, 050710071 (2011) STANDARDISASI DAN PROFIL KLT-DENSITOMETRI DAN FTIR SIMPLISIA PERIKARPIUM MANGGIS (Garcinia mangostana L.). Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Pericarpium of mangosteen ( Garcinia mangostana Linn.) of which a major active component is α -mangostin, has been popularly used as anticancer which mechanism inactivated mitochondria of cancer cell. From its uses, the pericarpium will be developed as standa rized herbal drug. The source and quality of raw materials play a pivotal role in guaranteeing the quality and stability of herbal preparations. Thus, proper standa rdization and quality control of raw material and the herbal preparations themselves should be carried out. This study was conducted to standari ze the raw material of mangosteen and to see the chromathograme profile obt ained by TLC-Densitometric and FTIR in pericarpium of mangosteen collected from Trenggalek. In this stage, specific and non specific parameters of raw material are conducted. The result showed non-specific paramete rs of raw material were total ash was (2,48 ± 0,06)%, acid in soluble ash was (2,31±0,18)%, water soluble ash was (0,73±0,05)%, water content was (7,58±0,30)% and loss on drying was (10,41±0,03)%. For Pb content was 0,178 ppm, Hg and As content were 0, Cd content was 0,012 ppm and Cu content was 0,142 ppm. The specific parameters of raw mate rials showed that water soluble extractive substance was (11,01±0,42)%w/w, alcohol sol uble extractive substance was (13,14±0,42)%w/w. The linearity was found over the range of 50-200 μ g/ml with regression coefficient ( r ) 0.9996. Precisions showed relative standard deviation (%RSD) 4,39 %. Accuracy of the method was determined by a recovery study and the average was found to be 99,19 %. The total mangostin contents in all dried powder samples were in the range of 13.94±0.8 % w/w. This information will be useful as a guidance for standardization of pericarpium Garcinia mangostana L .
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK-2 FF 328 11 Riw s | |||||||||
| Uncontrolled Keywords: | Garcinia mangostana,mangosteen, standardization,α-mangostin | |||||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica | |||||||||
| Divisions: | 05. Fakultas Farmasi > Farmakognosi Fitokimia | |||||||||
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| Depositing User: | Dwi Marina | |||||||||
| Date Deposited: | 27 Jan 2012 12:00 | |||||||||
| Last Modified: | 25 Jul 2016 02:34 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/9605 | |||||||||
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