SUKMANING AYUNDA, 050911025 (2013) PENGARUH KADAR POLYPLASDONE XL-10 DALAM COPROCESSED EXCIPIENTS MANITOL � POLYPLASDONE XL-10 � GELATIN TERHADAP MUTU FISIK DAN DISOLUSI ORALLY DISINTEGRATING TABLET PARASETAMOL (Dibuat dengan Metode Cetak Langsung). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The aim of this study was to determine the effect of Polyplasdone XL 10 5% and 10% as a superdisintegran in coprocessed excipients mannitol − Polyplasdone XL-10 – gelatin 2% on the physical quality (thickness, hardness, friability, disintegration time, wetting time) and dissolution of paracetamol ODT made by direct compression. Tablets were made to contain 120 mg paracetamol/tablet and pressed by hydraulic press for 1 ton. Tablets were evaluated for thickness, hardness, friability, disintegration time, wetting time and dissolution. The results showed that mechanical strength of the tablet containing Polyplasdone XL 10 10% in coprocessed excipients was better than the tablet containing Polyplasdone XL 10 5% in coprocessed excipients, but there was no difference in thickness. The friability of both formula were less than 1%, disintegration time were less than 60 seconds, and percent dissolved within 30 minutes were more than 80%.

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