PUTRI THIRZA EKARANI, 050911032 (2013) PENGARUH KADAR POLYPLASDONE XL-10 TERHADAP KARAKTERISTIK COPROCESSED EXCIPIENT MANITOL-POLYPLASDONE XL-10- PVP K-30 UNTUK ORALLY DISINTEGRATING TABLET(Dibuat dengan Metode Fluid Bed Granulation). Skripsi thesis, UNIVERSITAS AIRLANGGA.

Preview	Text (ABSTRAK) ABSTRAK.pdf Download (245kB) | Preview
	Text (FULLTEXT) FULLTEXT.pdf Restricted to Registered users only Download (2MB) | Request a copy

Abstract

The effect of Polyplasdone XL-10 as superdisintegrant on characteristics of coprocessed excipient mannitol-Polyplasdone XL-10-PVP K-30 prepared by Fluid Bed Granulation method was observed in this research. Coprocessed excipient were prepared with two different concentration of Polyplasdone XL-10 (5% and 10% by weight of the composition). The granules were evaluated physically and surface area of granules were examined using Scanning Electron Microscope (SEM). The result showed that increasing Polyplasdone XL-10 concentration increased compressibility, compactibility, dilution potential and decreased flow rate and disintegration time. Based on statistical analysis using Independent sample t test they were significantly different except the angle of repose. This research concluded that the addition of 10% Polyplasdone XL-10 as a superdisintegrant gave faster disintegration time and higher compactibility than 5% Polyplasdone XL-10. Characterization using SEM showed that surface of the granules were not spherical, even though there were no difference between two formulations visually.

Actions (login required)

View Item