Viskasari Pintoko Kalanjati and M. W. Hendrata and F. N. Ardana (2019) Cellular Composition in the Aging Cerebral Cortex of Humans. Neurophysiology, 51 (6). pp. 424-429. ISSN 09441344

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Abstract

The numbers/densities of neurons and gliocytes and the neuron-to-glia ratios were calculated in different layers of the cerebral cortex of three subjects in a post mortem study. The subjects were 60 to 70 years old (which was qualified as a relatively early period of aging) and had no history of neurodegeneration diseases. The brains embalmed in 10% formalin-fixative solution were processed, and coronal 4-μm-thick slices of tissues of the frontal, parietal, temporal, and occipital lobes were prepared and stained with hematoxylin-eosin. Clear cortical lamination was observed in all lobes. In the frontal lobe, the mean neuron density (number of neurons within visual fields at a 400× magnification) was significantly higher, while that of gliocytes was significantly lower compared to the respective values in other lobes (P < 0.05). A significant association between the number of neurons and glia was found in the frontal lobe (r2 = 0.40, P = 0.0029) and in all superficial cortical layers (r2 = 0.72, P = 0.0025), but not in the deeper layers (r2 = 0.18, P = 0.14). The mean neuron-to-glia ratio in different lobes and layers varied from 1.0 : 0.81 to 1.0 : 3.54. It is concluded that, in early-aging subjects with no cerebral pathology, the quantitative characteristics of cortical neurons and glial cells do not differ significantly from those in the brains of younger adult healthy subjects.

Item Type:	Article
Uncontrolled Keywords:	neurons, gliocytes, neocortex, cortical zones, neuron-to-glio ratio, aging, humans
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Divisions:	01. Fakultas Kedokteran > Ilmu Anatomi Histologi
Creators:	Creators NIM Viskasari Pintoko Kalanjati NIDN0020037604 M. W. Hendrata UNSPECIFIED F. N. Ardana UNSPECIFIED
Depositing User:	arys fk
Date Deposited:	03 Aug 2020 01:35
Last Modified:	03 Aug 2020 01:35
URI:	http://repository.unair.ac.id/id/eprint/96382
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