Alexander Patera Nugraha, - and Diah Savitri Ernawati, - and Adiastuti Endah P, - and Bagus Soebadi, - and Erwin Astha Triyono, - and Remita Adya Prasetyo, - and Sulistyowati Budi, - (2017) Correlation Linear Gingival Erythema, Candida Infection and CD4+ Counts in HIV/AIDS Patients at UPIPI RSUD Dr. Soetomo Surabaya, East Java, Indonesia. Journal of International Dental and Medical Research, 10 (2). pp. 322-326. ISSN 1309-100X

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Abstract

East Java has been 2nd highest province with HIV/AIDS cases in Indonesia on 2013. Oral manifestations are among the earliest and most important indicator of HIV infection progression. Linear Gingival Erythema (LGE) is the one of seven oral manifestation which associated with HIV Infection. Clinical feature of LGE is a distinctive fiery red band along the margin of the gingiva. The etiology and pathogenesis of LGE are still questionable, but a candidal infection and decreased of CD4+ counts has been suggested. The aim of this study was to investigate LGE with its correlation with Candida infection and decreased level of CD4+ in HIV/AIDS patient. This study was an analytical observational research with cross-sectional and total sampling method. The samples consisted of 88 HIV/AIDS patients treated in UPIPI RSUD Dr. Soetomo Surabaya from July-August 2014 were recruited for Candida microbial screening on LGE lesion. Clinical specimens including oral swabs were collected. Diagnosed of LGE by clinical appearance, the oral cavity of research subjects examined by oral medicine specialist. CD4+ counts obtained from patient's medical record. 88 HIV/AIDS patients were examined, there were 7 cases (5,83%) LGE, 7 from 7 gingival margin found Oral Candidiasis (OC) (100%). LGE was found to be significantly correlated to OC and decreased CD4+ counts < 200 cells/mm3 (p<0.05). LGE related to candida infection and decreased CD4+ counts in HIV/AIDS patients.

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