RANGGA ANDHIKA WIJAYANDARU, 050911107 (2013) PENGARUH KOMBINASI LIPID BEESWAX-GLISERIL MONOSTEARAT TERHADAP AKTIVITAS ANTIINFLAMASI SISTEM SLN-APMS. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The purpose of this experiment is to know the anti-inflammatory activity of SLN-APMS system with the combination of lipid system beeswax-gliseril monostearat. The outcome of this experiment would subsequently be a scientific foundation for formulating a topical preparation of p-methoxynamic acid which safe, effective, and having quality. This research used the complete random design, with 20 Wistar male rats which 7-8 weeks old and 115-200 g. They were divided into six groups. Group I was treated formula I which using combination lipid beeswax:GMS 100:0. Group II was treated negative control which using combination lipid beeswax:GMS. Group II was treated formula II which using combination lipid beeswax:GMS 50:50. Group III was treated formula III which using combination lipid beeswax:GMS 0:100. Group IV was treated negative control which using combination lipid beeswax:GMS 100:0. Group V was treated negative control which using combination lipid beeswax:GMS 50:50. Group VI was treated negative control which using combination lipid beeswax:GMS 0:100. The survey of hind paw oedema was done in 8 hours. From this data, it could be calculated the value of AUC of the oedema’s thickness to the time, and then the researcher determined the percentage of antiinflammatory capacity. The result showed that the effect of antiinflammatory to the Carragenan-induced paw oedema in rats was significant. The most effective was FII, then the second was F1, and the less effective was FIII.

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