META FERIZA, 051011166 (2013) PENGARUH JUMLAH KALSIUM KLORIDA TERHADAP KARAKTERISTIK FISIK NANOPARTIKEL FRAKSI DITERPENLAKTON SAMBILOTO-KARBOKSIMETIL KITOSAN (Dibuat Dengan Metode Gelasi Ionik). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The objective of this study was to investigate the effect of calcium chloride (CaCl2) on physical characteristic (particle size, morphology, and drug entrapment efficiency) of diterpenelacton fraction from Andrographis paniculata-carboxymethyl chitosan nanoparticle. The nanoparticles were prepared by ionic gelation with 40mg (F1), 120mg (F2), 160mg (F3), 200mg (F4) of CaCl2 for CM Chitosan and dried by spray drying. The result showed that CaCl2 has effect on physical characteristic of that. Nanoparticles was obtained from the ionic gelation. These particle became larger after the drying. The dried particles with irregular hollow shape was obtained from lower CaCl2. In other hand, the agglomerate particles obtained from F3 and F4 indicated higroscopicity since higher amount of CaCl2 increased. Based on the infrared spectrum, there was ionic bonding of carboxymethyl chitosan and calcium chloride. The higher amount of CaCl2 (80 mg to 120 mg) increase the drug entrapment efficiency. The further study of the optimal CM Chitosan and CaCl2 consentration still needed to gain the homogenous and spherical nanoparticles.

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